Dec 18, 2017 for psychotic patients who have been stabilized on a fixed daily dosage of orally administered fluphenazine hydrochloride dosage forms, conversion to the longacting injectable fluphenazine decanoate may be indicated see package insert for fluphenazine decanoate injection for conversion information. Plasma concentrations of the active neuroleptic drugs, zuclopenthixol and fluphenazine, were determined by high performance liquid. Considerations in establishing expiration dates for. Brain problem, liver disease, or low blood cell count. Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients, psychoneurotic patients or geriatric patients with confusion andor agitation. Fluphenazine decanoate definition of fluphenazine decanoate. Seventeen outpatients were treated with depot neuroleptics, zuclopenthixol decanoate in viscoleo or fluphenazine decanoate in sesame oil, with dosage intervals of 3 weeks. Patients who have shown hypersensitivity to other phenothiazines, including fluphenazine, should not be given fluphenazine decanoate. Fluphenazine belongs to a class of medications called phenothiazines and is also referred to as a neuroleptic. Jun 27, 2017 for psychotic patients who have been stabilized on a fixed daily dosage or orally administered prolixin fluphenazine hydrochloride dosage forms, conversion to the longacting injectable prolixin fluphenazine decanoate may be indicated see package insert for prolixin decanoate fluphenazine decanoate injection for conversion information. These interactions can increase a persons risk of developing side effects or cause the medications to become less effective. Fluphenazine, sold under the brand names prolixin among others, is an antipsychotic medication.
Fluphenazine decanoate dihydrochloride united states pharmacopeia usp reference standard cas number 2376650. Fluphenazine decanoate, fluphenazine decanoate manufacturers. Clinical pharmacology the basic effects of fluphenazine decanoate appear to be no different from those of fluphenazine hydrochloride, with the exception of duration of action. The presence of blood dyscrasia or liver damage precludes the use of fluphenazine decanoate. Empirical formula hill notation c 32 h 44 f 3 n 3 o 2 s 2hcl. It is a highly potent behavior modifier with a markedly extended duration of effect. Prolixin decanoate fluphenazine decanoate is longacting medicine for stabilizing your mood that must be given by a trained healthcare professional. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for prolixin decanoate fluphenazine decanoate. Fluphenazine depot injection solutions must be drawn up using a dry syringe and a needle of at least 21gauge. With any given phenothiazine derivative, the incidence and severity of such.
On day 28, the recommended dose of haloperidol decanoate was 75 mg. Administration of haloperidol decanoate in sesame oil results in slow and. Fluphenazine decanoate injection is not intended for use in children under 12 years of age. It is given by mouth, injection into a muscle, or just under the skin. Effectiveness of paliperidone palmitate vs haloperidol decanoate. Fluphenazine decanoate injection, usp package insert one can expect a higher incidence with fluphenazine decanoate than with less potent piperazine derivatives or with straightchain phenothiazines such as chlorpromazine. Fluphenazine decanoate and fluphenazine enanthate are depot injection formulations should not be utilized in patients with hepatic impairment. No precise formula can be given to convert to use of fluphenazine decanoate. Treatment of schizophrenia with longacting fluphenazine. Fluphenazine decanoate is usually used in patients who have benefited from regular doses of shortacting forms of fluphenazine and who may benefit from longterm maintenance treatment with less frequent dosing. Subcutaneous injection fluphenazine decanoate or fluphenazine enanthate. Check with your physician if you have any of the following.
Treatment for a prolixin overdose the treatment for a prolixin overdose will vary as well. Fluphenazine decanoate injection is contraindicated in comatose or severely depressed states. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Pdf compatibility and stability of drug products and. Comparative study of the pharmacokinetics of zuclopenthixol. Three corporate drive lake zurich, illinois 60047 general phone number. However, once the drug has been absorbed into the body, there is no treatment that can remove it quickly. A comparative trial of haloperidol decanoate and fluphenazine. For complete ordering information, please contact your local pharmaceutical distributor.
Depottype phenothiazines fluphenazine enanthate fluphenazine decanoate avoidance. Prescribing information prfluphenazine fluphenazine hydrochloride tablets usp 1 mg, 2 mg, and 5 mg therapeutic classification antipsychotic pharmacology phenothiazine derivatives appear to act on the hypothalamus, depressing various components of the. If you require any further information or you are unsure about anything, ask your doctor or pharmacist. The empiric formula is c32h44f3n3o2s and the molecular weight 591. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Fluphenazine can cause mild and transient serum enzyme elevations and has been linked to rare instances of clinically apparent cholestatic liver injury. Prolixin decanoate fluphenazine decanoate fda package. The products dosage form is injection, and is administered via intramuscular. Dailymed fluphenazine hydrochloride solution, concentrate. Prescribing information prfluphenazine fluphenazine. The basic effects of fluphenazine decanoate appear to be no different from those of fluphenazine hydrochlo ride, with the exception of duration of action.
Modecate, modecate concentrate fluphenazine dosing. Comparison of the effects of different routes of antipsychotic administration on. Product information modecate fluphenazine decanoate oily injection name of drug fluphenazine decanoate. Fluphenazine decanoate fluphenazine decanoate dose. Fluphenazine side effects, dosage, interactions drugs. Fluphenazine decanoate injection is a sterile solution of fluphenazine decanoate in a suitable vegetable oil. Fifteen of the 55 study patients took olanzapine mean dose, 18. Fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. Fluphenazine decanoate injection, usp manufacturer name. Find patient medical information for fluphenazine decanoate bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Capitals indicate lifethreatening, underlines indicate most frequent. Fluphenazine decanoate injection auromedics pharma llc. Find patient medical information for fluphenazine decanoate injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Fluphenazine decanoate injection, usp package insert. Fluphenazine decanoate injection, usp par sterile products. During the 4th, 6th, and 8th dosage interval blood samples were drawn in oxalated tubes. Fluphenazine decanoate dihydrochloride united states. Have blood work checked as you have been told by the doctor. Fluphenazine decanoate has activity at all levels of. It is used in the treatment of chronic psychoses such as schizophrenia, and appears to be about equal in effectiveness to lowpotency antipsychotics like chlorpromazine.
Fluphenazine administration to horses may result in characteristic clinical signs of toxicity. Nov 09, 2018 fluphenazine is an antipsychotic medicine in a group of drugs called phenothiazines feenohthyeazeens. If you need to stop fluphenazine decanoate injection, you will want to slowly stop it as ordered by your doctor. Our products are available from authorized distributors. Fluphenazine decanoate or enanthate injections are administered via im or subcutaneous injection only, do not administer intravenously. Comparison of the effects of different routes of antipsychotic administration on pharmacokinetics and pharamcodynamics. It is a highly potent behavior modifier with a markedly extended dura tion of effect and has the following structural formula. Product information modecate fluphenazine decanoate oily. It is used to find the right dose for you before moving to a longacting injection. Fd denotes fluphenazine decanoate, hd denotes haloperidol decanoate, and lar. Oral fluphenazine dosing the recommended dose when starting the drug is fluphenazine 2. This represents an approximate conversion ratio of 0. Neurological disease, parkinsons disease antipsychotics can cause motor and sensory instability, which may lead to falls with the potential for fractures and other injuries.
Store at 20 to 25c 68 to 77f see usp controlled room temperature. Pharmacokinetics of haloperidol decanoate abstract. Dec 10, 2018 fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. Fluphenazine decanoate injection, usp is available as a clear, pale yellow solution for. List of approved drug products containing fluphenazine decanoate in the fda orange book on. There was little drug effect on the 24 h drinking pattern after the first 24 h. If the overdose was recent, the healthcare provider may use certain medicines or place a tube into the stomach to pump the stomach. Drug interactions with fluphenazine can occur when the medication is combined with prozac, paxil, and lamisil, for example. Effects of fluphenazine enanthate and fluphenazine decanoate on. Fluphenazine decanoate medicinal forms bnf content. List of the 8 ndc products with the active ingredient fluphenazine decanoate.
Fluphenazine decanoate full prescribing information. Fluphenazine decanoate injection, usp is available as a clear, pale yellow. Pricing, sizing, legal catgories and other medicinal forms information for fluphenazine decanoate. Fluphenazine decanoate injection, usp is a sterile injection, available for intramuscular or subcutaneous administration, providing 25 mg fluphenazine decanoate per ml. Feb 05, 2020 do not stop taking fluphenazine decanoate injection all of a sudden without calling your doctor.
Fluphenazine decanoate, a human prescription drug labeled by westward pharmaceuticals corp. Qualitative and quantitative composition each 1ml contains fluphenazine decanoate bp 25mg. Chapter 37 compatibility and stability of drug products and preparations 683 lwbk127c37671701. Haldol decanoate 50 haloperidol haldol decanoate 100. In horses, fluphenazine decanoate has been used to provide a persistent sedative effect.
Fluphenazine decanoate fda orange book approved drug. Whats in your medicine fluphenazine decanoate injection bp is a clear, lightyellow, sterile injection in clear glass ampoules. The ndc code 0143952901 is assigned to fluphenazine decanoate also known as. Description chemically fluphenazine decanoate is 2432trifluoromethyl10hphenothiazin10ylpropyl piperazin 1yl ethyl decanoate. Fluphenazine is an antipsychotic medicine in a group of drugs called phenothiazines feenohthyeazeens. Get fluphenazine decanoate at best price with product specifications. If you have an allergy to fluphenazine or any other part of fluphenazine decanoate injection.
The authors and the publisher have exerted every effort to. The following conditions are contraindicated with this drug. It works by changing the actions of chemicals in your brain. Fluphenazine decanoate injection, usp is available as a clear, pale. The ester ification of fluphenazine markedly prolongs the drugs duration of effect without unduly attenuating its bene ficial action. Fluphenazine is a phenothiazine and antipsychotic agent which is no longer in common use.
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